Royal Air Force Typhoon FGR4s have joined forces with French aircraft in a joint strike targeting an underground arms cache in Syria employed by the IS group, per a report from the UK's MoD.
The site, identified by surveillance, was assessed as housing weapons and explosive materials, the announcement noted, and was located in hills just to the north of Palmyra in central Syria.
"Our aircraft employed Paveway IV guided bombs to strike a several access tunnels leading to the depot... preliminary assessments indicate the strike was effective," the ministry announced.
There was no evidence of any civilian casualties in the strike conducted Saturday night and every plane involved returned to base without incident, the MoD added.
The British jets were supported by a Voyager tanker plane.
IS - referred to as Daesh - enforced jihadist rule over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This action demonstrates the UK's leading role, and determination to operate in unison with our partners, to eliminate any revival of Daesh and their harmful and extremist ideologies in the region," Britain's Defence Chief John Healey said.
UK warplanes have carried out overwatch operations over Syria to "forestall any attempted resurgence" of the group subsequent to its defeat at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to every member of our armed forces involved in this mission for their professionalism and their valour," he said. "They were among thousands of UK service members deployed over Christmas and New Year. This mission, to eliminate militants who threaten our security, highlights how UK forces are always on standby, continuously, keeping Britain secure at home and strong abroad."
During December, the American forces conducted what it termed a "large-scale strike" targeting Islamic State objectives in Syria, after an attack killed two US servicemembers and a local interpreter in Palmyra.
The United Nations reports Islamic State still maintains between 5,000 and 7,000 combatants in both countries.